Trade is an important part of economic activities that takes place in the world. Every day, tones of goods and services change hand between individuals and between countries. Being an important economic activity in the world, trade is governed by different rules and regulations that are geared towards ensuring there is a fair play ground between all parties. World Trade Organization (WTO) is the main organ that is bestowed with responsibility of ensuring there is a fair play ground between trading partners. It ensures enactment and enforcement of trade rules between member countries. Trade in food items constitutes a sizable share of world trade. Because countries are endowed with different resources, there are those with surplus food items while others have a deficiency necessitating trade. Considering the nature of foods, WTO has put in various rules and regulations that govern trade in food items. Two most important are the Agreement on the Application of Sanitary and Phytosanitary Measures (SPS Agreement) and Codex Alimentarius. In enforcing these agreements, WTO partners with other bodies like World Health Organization (WHO) and Food and Agriculture Organization (FAO). This paper will look into the relationship between Codex Alimentarius Commission, World Trade Organization and the Sanitary and Phytosanitary Measures Agreement.