Since the Industrial Revolution, the world has experienced major advancements in all spheres of life. Most of these advancements are anchored on scientific research. Scientific research involves structured method of inquisition that leads to discovery of new knowledge. The contemporary advancement in medicine, technology, education, construction, and many other areas of knowledge traces foundation for scientific research. Despite this progress, scientific research comes with troubling ethical issues. The beginning of the 20th century ushered the world to an era of intensive scientific research, through which important knowledge, especially in the area of medicine and social services, was generated. However, it also turned out to be one of the most troubling periods in ethical research, because of the use of human subjects in experiments like Little Albert, Milgram’s Obedience, Zimbardo Prisoner Stanford Experiment, and others (Benjamin, 2014). These are the evolving ethical issues during this period that led to the establishment of the Belmont Report by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, which outlines the important ethical principles that should be observed when dealing with human subjects. This study looks into the historical research and publication of the Belmont Report, including ethical controversies that led to this development.