Fatty infiltration of the liver in cattle is a condition that is mainly characterized by fatty liver, which is common in periparturient cattle. Although this condition is considered as a postpartum disorder, it has been shown to develop before and even during parturition. According to West (1990) this condition is associated with endocrine changes that occur during parturition and lactogenesis. The endocrine changes during these periods contribute to development of fatty liver that in most cases is followed by severe cases. West (1990) show that cows that are more likely to be overburdened during calving are more likely to develop the condition compared to other cows. Fatty infiltration can develop in incidence where there is less intake of feed and it is also secondary after onset of other disease conditions. Cows that develop these conditions are also susceptible to development of ketosis. Fatty liver condition has been found prevalent among dairy cows. In most cases, dairy cows do not store fat in the liver, which means fatty liver does not happen when the cow has increased its body condition and puts on more fat. It occurs when the cow breaks down a large amount of fat thereby burdening the liver and making it difficult for the liver to complete the breakdown process. The broken down fats products are usually converted back to fat in the liver in order to prevent them from being toxic. Therefore, the liver accumulates more fat as the cow loss its body condition and the more the loss in body condition, the fat the liver becomes. According to Morrow (1996) this is a severe condition that may result to loss of livestock. It may result to high morbidity as high as 50-90 percent and death rate as high as 25 percent. The best way to manage this condition is through creating positive energy balance. This study will look at fatty infiltratin of the liver in cattle. The study will look at the cause of the condition, etiology, clinical findings and diagnosis, and finally it will look at treatment and prevention of the condition.