Family therapy considers family as a distinct social system with unique structure and communication patterns. The family is viewed as an emotional unit (Corey, 2013). The selected article for this discussion is Akram, Copello and Moore’s (2014) systematic review, “Family based interventions for substance misuse: a systematic review of systematic reviews-protocol”. The aim of this systematic review is to integrate the vastness of research on the effectiveness of family-based interventions in substance abuse. The study’s inclusion criteria: systematic reviews; population includes individuals who have substance misuse problems; and interventions with a family-focused component. Reviews that focus on prevention rather than treatment are excluded. Focus on intervention entails “promoting engagement of user into treatment/joint involvement in treatment of user/treating family member in own right (Akram et al., 2014, p. 90). Focus is particularly on adolescents and adults alcohol and/or drug misusers to enable evaluation of the vastness of existing evidence.