Cognitive aging and the role of the endocannabinoid system in the zebrafish


I need the theory part of my thesis.


During the last few years the endocannabinoid system has been linked to a number of different managing activities. Endogenous cannabinoids operate at CB1 level stimulating a strong craving for food hence resulting in the enhancement of body weight as reported in a study by Elphick and Egertova  (2000 , pp. 381). Maintenance of body weight and energy homeostasis needs the coordinated control of hunger behaviors and side-line power metabolic capacity as verified by the capability of the endocannabinoid system to connect with leptin, the appetite-reducing hormonal agent, system blood insulin and cholestrerol levels in the management of fat metabolic rates (Pan et al. 2011, pp. 13420). A study conducted by Marsicano et al. (2002, pp. 530) on obesity in rats or rodents showed that a serious impediment of CB1 receptor activates a significant loss of fat mass respect to muscular huge. These findings confirmed what was found in a similar study by Meredith et al. (2003, pp. 11142) who explained the endocannabinoids as “novel fat arbitrators”. In the study, knock out rodents for CB1 fed on a traditional diet plan right from the beginning.