Much of America history is recorded from the time Columbus and his team of explores landed in the Caribbean region. The first reaction to establishment of Spanish in the Caribbean region was the policy of extermination in which millions of the original inhabitants lost their life. Although it has become controversial on the exact number of inhabitants living in the region before the coming of the Columbus, it remains clear there were a large number of indigenous people and the coming of Columbus really changed their life. The nature of the Native Americans remains a controversial issue since it is argued that on his arrival Christopher Columbus mistook the inhabitants for Indians. This is because he though he had arrived in East Indies since he was seeking sea route to India.